04 August 2020 : Laboratory Research
Role and Mechanism of Maresin-1 in Acute Lung Injury Induced by Trauma-Hemorrhagic Shock
Huayi Ma1ABCDEFG, Song Mo1ABCDEFG, Qushen Yi1BCD, Junhua Lai1BF, Huan Liu1BEFG*, Zhanying Shi2BEFGDOI: 10.12659/MSM.923518
Med Sci Monit 2020; 26:e923518
Figure 1 MaR1 reduced BALF/plasma EDB ratio, lung permeability index and wet/dry weight ratio in acute lung injury induced by THS. A lung injury model was induced by THS before intravenously injection of 10 ng/mL MaR1 or 0.1 mL/100 g physiological saline. (A) lung permeability to EBD was conducted. (B) lung permeability activity. (C) Wet/Dry weight ratio. *, ** P<0.05, 0.01 versus Sham; #, ## P<0.05, 0.01 versus THS+saline group. MaR1 – Maresin-1; BALF – bronchoalveolar lavage fluid; THS – trauma hemorrhagic shock; qRT-PCR – quantitative real-time polymerase chain reaction; mRNA – messenger RNA.