04 August 2020 : Laboratory Research
Role and Mechanism of Maresin-1 in Acute Lung Injury Induced by Trauma-Hemorrhagic Shock
Huayi Ma1ABCDEFG, Song Mo1ABCDEFG, Qushen Yi1BCD, Junhua Lai1BF, Huan Liu1BEFG*, Zhanying Shi2BEFGDOI: 10.12659/MSM.923518
Med Sci Monit 2020; 26:e923518
Figure 5 MaR1 suppressed the activation of p38MAPK/NF-κB pathway in acute lung injury stimulated by THS. Western blot assay and qRT-PCR analyses were adopted to evaluate the proteins and relative genes expressions of p38MAPK/NF-κB pathway in different groups. (A) protein expression of p-p65 and p-p38 in lung tissues. The ratio of p-p65/p65 (B) and p-p38/p38 (C) were quantified. The mRNA levels of p65 (D) and p38 (E) in different groups were determined using qRT-PCR. ** P<0.01 versus Sham; #, ## P<0.01 versus THS+saline group. MaR1 – Maresin-1; THS – trauma hemorrhagic shock; qRT-PCR – quantitative real-time polymerase chain reaction; mRNA – messenger RNA.