Atorvastatin Enhances Effects of Radiotherapy on Prostate Cancer Cells and Xenograft Tumor Mice Through Triggering Interaction Between Bcl-2 and MSH2

Zhenhua He; Jingmin Yuan; Fuhui Shen; Fangang Zeng; Ping Qi; Zhiping Wang; Zhenxing Zhai

doi:10.12659/MSM.923560

01 September 2020 : Laboratory Research

Atorvastatin Enhances Effects of Radiotherapy on Prostate Cancer Cells and Xenograft Tumor Mice Through Triggering Interaction Between Bcl-2 and MSH2

Zhenhua He^1ABCDEFG*, Jingmin Yuan^1BCDEF, Fuhui Shen^2BCDF, Fangang Zeng^2BCDF, Ping Qi^3BCD, Zhiping Wang^4BCF, Zhenxing Zhai^4BF

DOI: 10.12659/MSM.923560

Med Sci Monit 2020; 26:e923560

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Figure 6 Determination for the effects of irradiation (IR) and/or atorvastatin (AS) administration on MSH2 mRNA expression in PCa cells. (A) Statistical analysis for MSH2 mRNA expression in PC3 cells. (B) Statistical analysis for MSH2 mRNA expression in DU145 cells. (C) Statistical analysis for MSH2 mRNA expression in Lncap cells. * P<0.05 versus PC3 or DU145 or Lncap group. #P < 0.05 versus PC3+IR or DU145+IR or Lncap+IR group.

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Atorvastatin Enhances Effects of Radiotherapy on Prostate Cancer Cells and Xenograft Tumor Mice Through Triggering Interaction Between Bcl-2 and MSH2

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