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30 August 2020: Animal Study

Promoting Role of Long Non-Coding RNA Small Nucleolar RNA Host Gene 15 (SNHG15) in Neuronal Injury Following Ischemic Stroke via the MicroRNA-18a/CXC Chemokine Ligand 13 (CXCL13)/ERK/MEK Axis

Tiezhu Guo 1AB , Yueting Liu 2CE , Xinliang Ren 1DE , Wei Wang 1EF , Hanrui Liu 3F*

DOI: 10.12659/MSM.923610

Med Sci Monit 2020; 26:e923610

Figure 5 The ERK/MEK antagonist reverses the roles of SNHG15 siRNA and miR-18a mimic in N2a cells. An ERK/MEK antagonist, U0126, was introduced into N2a cells with silenced SNHG15 or overexpressed miR-18a. (A) Viability of N2a cells was detected using EdU labeling assay. (B, C) Apoptosis of OGD-treated N2a cells was detected using Hoechst 33258 staining (B) and flow cytometry (C), respectively. Data are shown as meanĀ±SD based on 3 independent experiments. * p<0.05. Data were analyzed using one-way ANOVA.

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750