02 July 2020: Clinical Research
Nuclear Factor κB/MicroRNA-155 Upregulates the Expression Pattern of Cytokines in Regulating the Relapse of Chronic Sinusitis with Nasal Polyps and the Underlying Mechanism of Glucocorticoid
Jianbin Du 1BCE , Haijun Lv 2BC , Xin Dou 3BC , Zhongsheng Cao 1ADEF*DOI: 10.12659/MSM.923618
Med Sci Monit 2020; 26:e923618
Figure 1 Expression of NF-κB/miR-155 in patients. (A) Western blot analysis of p-IKK, p-p65, and IκB-α in Eos CRSwNP, Non-Eos CRSwNP, CRSsNP, and control group. (B–D) Statistical analysis displayed compared with Non-Eos CRSwNP, CRSsNP, and control group, the expression of p-IKK and p-p65 were significantly elevated while the expression of IκB-α was decreased in Eos CRSwNP group. (E) In situ hybridization of miR-155 in patients. Scale bar=100 μm (F) Statistical analysis displayed the number of miR-155 positive cells were significantly increased in Eos CRSwNP group. * P<0.05; ** P<0.01. NF-κB – nuclear factor κB; CRSsNP – chronic rhinosinusitis without nasal polyps; Non-Eos CRSwNP – non-eosinophilic chronic rhinosinusitis with nasal polyps; Eos CRSwNP – eosinophilic chronic rhinosinusitis with nasal polyps.