02 July 2020 : Clinical Research
Nuclear Factor κB/MicroRNA-155 Upregulates the Expression Pattern of Cytokines in Regulating the Relapse of Chronic Sinusitis with Nasal Polyps and the Underlying Mechanism of Glucocorticoid
Jianbin Du1BCE, Haijun Lv2BC, Xin Dou3BC, Zhongsheng Cao1ADEF*DOI: 10.12659/MSM.923618
Med Sci Monit 2020; 26:e923618
Figure 1 Expression of NF-κB/miR-155 in patients. (A) Western blot analysis of p-IKK, p-p65, and IκB-α in Eos CRSwNP, Non-Eos CRSwNP, CRSsNP, and control group. (B–D) Statistical analysis displayed compared with Non-Eos CRSwNP, CRSsNP, and control group, the expression of p-IKK and p-p65 were significantly elevated while the expression of IκB-α was decreased in Eos CRSwNP group. (E) In situ hybridization of miR-155 in patients. Scale bar=100 μm (F) Statistical analysis displayed the number of miR-155 positive cells were significantly increased in Eos CRSwNP group. * P<0.05; ** P<0.01. NF-κB – nuclear factor κB; CRSsNP – chronic rhinosinusitis without nasal polyps; Non-Eos CRSwNP – non-eosinophilic chronic rhinosinusitis with nasal polyps; Eos CRSwNP – eosinophilic chronic rhinosinusitis with nasal polyps.






