02 July 2020>: Clinical Research
Nuclear Factor κB/MicroRNA-155 Upregulates the Expression Pattern of Cytokines in Regulating the Relapse of Chronic Sinusitis with Nasal Polyps and the Underlying Mechanism of Glucocorticoid
Jianbin Du 1BCE , Haijun Lv 2BC , Xin Dou 3BC , Zhongsheng Cao 1ADEF*DOI: 10.12659/MSM.923618
Med Sci Monit 2020; 26:e923618
Figure 3 Expression of NF-κB/miR-155 in Eos CRSwNP patients with or without DEX treatment. (A) Western blot analysis of p-IKK, p-p65, and IκB-α in Eos CRSwNP-control and Eos CRSwNP-DEX group. (B–D) Statistical analysis displayed after DEX treatment, the expression of p-IKK and p-p65 were significantly decreased while the expression of IκB-α was significantly increased in Eos CRSwNP patients. (E) After DEX treatment, the expression of miR-155 was also decreased in Eos CRSwNP patients. NF-κB – nuclear factor κB; Eos CRSwNP – eosinophilic chronic rhinosinusitis with nasal polyps; DEX – dexamethasone.