02 July 2020 : Clinical Research
Nuclear Factor κB/MicroRNA-155 Upregulates the Expression Pattern of Cytokines in Regulating the Relapse of Chronic Sinusitis with Nasal Polyps and the Underlying Mechanism of Glucocorticoid
Jianbin Du1BCE, Haijun Lv2BC, Xin Dou3BC, Zhongsheng Cao1ADEF*DOI: 10.12659/MSM.923618
Med Sci Monit 2020; 26:e923618
Figure 3 Expression of NF-κB/miR-155 in Eos CRSwNP patients with or without DEX treatment. (A) Western blot analysis of p-IKK, p-p65, and IκB-α in Eos CRSwNP-control and Eos CRSwNP-DEX group. (B–D) Statistical analysis displayed after DEX treatment, the expression of p-IKK and p-p65 were significantly decreased while the expression of IκB-α was significantly increased in Eos CRSwNP patients. (E) After DEX treatment, the expression of miR-155 was also decreased in Eos CRSwNP patients. NF-κB – nuclear factor κB; Eos CRSwNP – eosinophilic chronic rhinosinusitis with nasal polyps; DEX – dexamethasone.