07 July 2020: Lab/In Vitro Research
Chlamydial-Secreted Protease Chlamydia High Temperature Requirement Protein A (cHtrA) Degrades Human Cathelicidin LL-37 and Suppresses Its Anti-Chlamydial Activity
Xiaohua Dong 1AB* , Wanxing Zhang 2CE* , Jianmei Hou 3DF , Miaomiao Ma 2DF , Congzhong Zhu 4DF , Huiping Wang 2AG , Shuping Hou 2AG*DOI: 10.12659/MSM.923909
Med Sci Monit 2020; 26:e923909
Figure 1 Recombinant cHtrA and cHtrA mutants (MT-H143A and MT-S247A) were identified by SDS-PAGE. Molecular weight of cHtrA (no matter wild-type or mutants) is 56KD. One μg/mL cHtrA can hardly be detected, but the bands of 10 μg/mL and 100 μg/mL cHtrA were clear on SDS gel.