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07 July 2020: Lab/In Vitro Research

Chlamydial-Secreted Protease Chlamydia High Temperature Requirement Protein A (cHtrA) Degrades Human Cathelicidin LL-37 and Suppresses Its Anti-Chlamydial Activity

Xiaohua Dong 1AB* , Wanxing Zhang 2CE* , Jianmei Hou 3DF , Miaomiao Ma 2DF , Congzhong Zhu 4DF , Huiping Wang 2AG , Shuping Hou 2AG*

DOI: 10.12659/MSM.923909

Med Sci Monit 2020; 26:e923909

Figure 5 cHtrA cleavage of LL-37 reverses anti-chlamydial activity on D and MoPn strains. C. trachomatis serovar D and MoPn strains were used to evaluate the cHtrA-mediated blockade of LL-37 anti-chlamydial activity. The colors of the tubes represent different experiment operates, and the details are contained in the legends. * P<0.05, ** P<0.01.

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750