Figure 6 Immune-correlation analyses of the prognostic signature in the TCGA-LUAD dataset. (A–C) The correlation scatter plots representing the correlation between risk score and immune-, stromal, and ESTIMATE-score. The value of spearman correlation coefficient (r) is presented. (D) The comparison of the tumor mutation burden (TMB) values between high-risk (n=90) and low-risk (n=400) patients. (E) Gene expression levels of immune checkpoints. PDCD1LG2 – programmed cell death 1 ligand 2; PDCD1 – programmed cell death 1; CTLA4 – cytotoxic T-lymphocyte associated protein 4; CD274 – programmed cell death 1 ligand 1; * P-value <0.05. (F) Gene expression levels of human leukocyte antigen (HLA) system; * P-value <0.05. (G) The violin plot for the analysis of immune cell infiltration. The fractions of 22 mature human tumor infiltration leukocytes (TILs) are compared between the high-risk (n=70) and low-risk (n=372) groups. Naive CD4 T cells with negative infiltration in all samples is excluded from the analysis.