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27 June 2020: Animal Study

Pyrroloquinoline Quinone Inhibits Oxidative Stress in Rats with Diabetic Nephropathy

Min Zhang 12ACD , Jiangzhao Zhang 3BE , Yan Xiong 2CF , Jiaqing Peng 2BF , Xiaoyan Wu 1AEG*

DOI: 10.12659/MSM.924372

Med Sci Monit 2020; 26:e924372

Figure 2 PQQ inhibits OS induced by STZ in DN. (A) Western blot detects GPX1 and GPX3 expression. (B) GPX1 mRNA. (C) GPX3 mRNA. (D) SOD content. (E) LDH content. (F) MDA content. (G) Flow cytometry was used to detect ROS levels. (H) Immunofluorescence detection of 8-OHdG expression (magnification: 200×). * Compared with the control group, P<0.05; # Compared with the DN group, P<0.05. PQQ – pyrroloquinoline quinone; OS – oxidative stress; STZ – streptozocin; DN – diabetic nephropathy; GPX – glutathione peroxidase; mRNA – messenger RNA; SOD – superoxide dismutase; LDH – lactate dehydrogenase; MDA – malondialdehyde; ROS – reactive oxygen species.

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750