27 June 2020 : Animal Research
Pyrroloquinoline Quinone Inhibits Oxidative Stress in Rats with Diabetic Nephropathy
Min Zhang12ACD, Jiangzhao Zhang3BE, Yan Xiong2CF, Jiaqing Peng2BF, Xiaoyan Wu1AEG*DOI: 10.12659/MSM.924372
Med Sci Monit 2020; 26:e924372
Figure 2 PQQ inhibits OS induced by STZ in DN. (A) Western blot detects GPX1 and GPX3 expression. (B) GPX1 mRNA. (C) GPX3 mRNA. (D) SOD content. (E) LDH content. (F) MDA content. (G) Flow cytometry was used to detect ROS levels. (H) Immunofluorescence detection of 8-OHdG expression (magnification: 200×). * Compared with the control group, P<0.05; # Compared with the DN group, P<0.05. PQQ – pyrroloquinoline quinone; OS – oxidative stress; STZ – streptozocin; DN – diabetic nephropathy; GPX – glutathione peroxidase; mRNA – messenger RNA; SOD – superoxide dismutase; LDH – lactate dehydrogenase; MDA – malondialdehyde; ROS – reactive oxygen species.