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27 June 2020: Animal Study

Pyrroloquinoline Quinone Inhibits Oxidative Stress in Rats with Diabetic Nephropathy

Min Zhang 12ACD , Jiangzhao Zhang 3BE , Yan Xiong 2CF , Jiaqing Peng 2BF , Xiaoyan Wu 1AEG*

DOI: 10.12659/MSM.924372

Med Sci Monit 2020; 26:e924372

Figure 3 PQQ inhibits high glucose-induced OS damage in NRK-52E cells. (A) CCK-8 method for detecting optimal culture concentration and time of PQQ. (B) Western blot detects SOD1 and SOD2 expression. (C) Protein analysis. (D) SOD1 mRNA. (E) SOD2 mRNA. (F) CAT activity. (G) GSH-Px content. * Compared with the control group, P<0.05; # Compared with the high glucose group, P<0.05. PQQ – pyrroloquinoline quinone; OS – oxidative stress; CCK-8 – Cell Counting Kit-8; SOD – superoxide dismutase; mRNA – messenger RNA; CAT – catalase; GSH-Px – glutathione peroxidase.

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750