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27 June 2020: Animal Study

Pyrroloquinoline Quinone Inhibits Oxidative Stress in Rats with Diabetic Nephropathy

Min Zhang 12ACD , Jiangzhao Zhang 3BE , Yan Xiong 2CF , Jiaqing Peng 2BF , Xiaoyan Wu 1AEG*

DOI: 10.12659/MSM.924372

Med Sci Monit 2020; 26:e924372

Figure 4 PQQ activates AMPK/FOXO3a pathway. (A) Western blot detects AMPK, p-AMPK, and FOXO3a expression. (B) p-AMPK/AMPK ratio. (C) AMPK mRNA. (D) FOXO3a mRNA. * Compared with the control group, P<0.05, # Compared with the high glucose group, P<0.05. PQQ – pyrroloquinoline quinone; AMPK – adenosine 5′-monophosphate-activated protein kinase; FOXO3a – forkhead box protein O3a; mRNA – messenger RNA.

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750