AEB-071 Ameliorates Muscle Weakness by Altering Helper T Lymphocytes in an Experimental Autoimmune Myasthenia Gravis Rat Model

Feng Jing; Wei Huang; Qian Ma; Sheng-jie Xu; Chang-jin Wu; Yu-xiu Guan; Bing Chen

doi:10.12659/MSM.924393

13 September 2020 : Animal Research

AEB-071 Ameliorates Muscle Weakness by Altering Helper T Lymphocytes in an Experimental Autoimmune Myasthenia Gravis Rat Model

Feng Jing^1AE, Wei Huang^1BC, Qian Ma^1BC, Sheng-jie Xu^1BC, Chang-jin Wu^2BC, Yu-xiu Guan^2BC, Bing Chen^1A*

DOI: 10.12659/MSM.924393

Med Sci Monit 2020; 26:e924393

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Figure 2 AEB-071 improved the clinical symptom of EAMG rats. (A) AEB-071 treatment reversed the body weight decline in EAMG rats. (B) AEB-071 treatment reduced the Lennon score in EAMG rats. (C) AEB-071 treatment reduced serum anti-AChR level in EAMG rats as measured by ELISA analysis after 10 days of drug intervention. The results are expressed as mean±SD (n=5 rats/group). * P<0.05 compared to control group; # P<0.05 compared to EAMG group; & P<0.05 compared to AEB-071+EAMG group.

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AEB-071 Ameliorates Muscle Weakness by Altering Helper T Lymphocytes in an Experimental Autoimmune Myasthenia Gravis Rat Model

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