Figure 7 Levels of expression of P16, E-cadherin, Notch1 and EGFR in MG-63 cells were analyzed by Western blotting. (A, B) P16 and E-cadherin proteins were decreased in MG-63 cells treated with cisplatin, curcumin C086, and curcumin C086+cisplatin. (C, D) Meanwhile, Notch1 and EGFR proteins were downregulated in MG-63 cells treated with cisplatin, curcumin C086, and curcumin C086+cisplatin. Data are expressed as the mean±SEM. * P<0.05 and ** P<0.01.