15 July 2020>: Clinical Research
Argatroban Increased the Basal Vein Drainage and Improved Outcomes in Acute Paraventricular Ischemic Stroke Patients
Shoufeng Liu 12AE* , Peipei Liu 2BCDEF* , Po Wang 3BC , Fang Zhang 4BD , Lijun Wang 5BD , Yu Wang 6BD , Hao Lu 7B , Xiaofeng Ma 4AG*DOI: 10.12659/MSM.924593
Med Sci Monit 2020; 26:e924593
Figure 1 Effect of argatroban on BVR drainage in acute ischemic stroke: trial profile. Sixty patients with acute paraventricular ischemic stroke and matched clinical characteristics, who were beyond the 4.5-hour window for alteplase when recruited, were randomized into 2 groups. Both groups received standard stroke therapy, and one group (n=30) also received 10 mg intravenous argatroban (twice daily for 7 days consecutively). Treatment began between 1 hour after a baseline MRI and 48 hours after symptom onset. NIHSS, mBI, and mRS were conducted. Lesion volume was measured by MRI on admission. MFV in the BVR was measured by TCD at baseline and on day 7 and day 90. BVR – basal vein Rosenthal; MRI – magnetic resonance imaging; NIHSS – National Institutes of Health Stroke Scale; MFV – mean flow velocity; TCD – transcranial Doppler ultrasonography.