Figure 3 Functional enrichment analysis of 919 DEGs and significant modular analysis based on PPI network. (A) Top 30 GO terms of GO: BP, GO: CC and GO: MF. (B) Top 30 KEGG terms. (C) PPI network of C3 module. (D) PPI network of TIMP1 module. In A, B, terms are sorted by the number of genes enriched. In C, D, red stands for upregulated and green stands for downregulated genes. The size of the node represents the number of proteins that interact with the specified protein. DEGs – different expressed genes; PPI – protein–protein interaction; GO – Gene Ontology; BP – biological processes; CC – cellular components; MF – molecular function; KEGG – Kyoto Encyclopedia of Gene and Genome.