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01 August 2020: Animal Study

Effects of Jian-Pi-Zhi-Dong Decoction on the Expression of 5-HT and Its Receptor in a Rat Model of Tourette Syndrome and Comorbid Anxiety

Dan Wang 1BE , Hui-ling Tian 2CF , Xia Cui 3DG , Qian Wang 3C , Fan Guo 3BC , Wen Zhang 3ABCDEFG* , Qi-sheng Tang 1AG*

DOI: 10.12659/MSM.924658

Med Sci Monit 2020; 26:e924658

Figure 6 Effects of treatment on the expression levels of 5-HT2C in the cortex and striatum of Tourette syndrome (TS) and comorbid anxiety rats. Western blot and quantitative polymerase chain reaction were performed to investigate changes in the expression of 5-HT2C and the effects of JPZDD on those levels. && P<0.01 versus the control group; ## P<0.01 versus the model group; ** P<0.01 versus Flx group. (A) 5-HT2C protein expression (n=3 per group, F=20.15, P=0.01; F=3.76, P=0.14). 1=control group; 2=model group; 3=Flx group; 4=JPZDD group. (B) 5-HT2C mRNA expression (n=6 per group, F=6.54, P=0.00; F=34.14, P=0.00). Model group, TS and comorbid anxiety model group; Flx group, fluoxetine hydrochloride group; JPZDD group, Jian-pi-zhi-dong decoction group.

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750