01 August 2020>: Animal Study
Effects of Jian-Pi-Zhi-Dong Decoction on the Expression of 5-HT and Its Receptor in a Rat Model of Tourette Syndrome and Comorbid Anxiety
Dan Wang 1BE , Hui-ling Tian 2CF , Xia Cui 3DG , Qian Wang 3C , Fan Guo 3BC , Wen Zhang 3ABCDEFG* , Qi-sheng Tang 1AG*DOI: 10.12659/MSM.924658
Med Sci Monit 2020; 26:e924658
Figure 7 Schematic representation of JPZDD effects on 5-HT system. JPZDD exerts an anti-tic and anti-anxiety effect on the 5-HT system in a rat model of Tourette syndrome (TS) and comorbid anxiety mainly by inhibiting the expression of 5-HT2C mRNA in the striatum, improved the relative deficiency of 5-HT, and further enhanced the excitability of 5-HT system. 5-HT, serotonin; 5-HT2CR, 5-HT type 2C receptor; JPZDD, Jian-pi-zhi-dong decoction.