Logo Medical Science Monitor

Call: +1.631.470.9640
Mon - Fri 10:00 am - 02:00 pm EST

Contact Us

Logo Medical Science Monitor Logo Medical Science Monitor Logo Medical Science Monitor

01 August 2020: Animal Study

Effects of Jian-Pi-Zhi-Dong Decoction on the Expression of 5-HT and Its Receptor in a Rat Model of Tourette Syndrome and Comorbid Anxiety

Dan Wang 1BE , Hui-ling Tian 2CF , Xia Cui 3DG , Qian Wang 3C , Fan Guo 3BC , Wen Zhang 3ABCDEFG* , Qi-sheng Tang 1AG*

DOI: 10.12659/MSM.924658

Med Sci Monit 2020; 26:e924658

Figure 7 Schematic representation of JPZDD effects on 5-HT system. JPZDD exerts an anti-tic and anti-anxiety effect on the 5-HT system in a rat model of Tourette syndrome (TS) and comorbid anxiety mainly by inhibiting the expression of 5-HT2C mRNA in the striatum, improved the relative deficiency of 5-HT, and further enhanced the excitability of 5-HT system. 5-HT, serotonin; 5-HT2CR, 5-HT type 2C receptor; JPZDD, Jian-pi-zhi-dong decoction.

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750