09 August 2020: Lab/In Vitro Research
Dishevelled Associated Activator Of Morphogenesis (DAAM) Facilitates Invasion of Hepatocellular Carcinoma by Upregulating Hypoxia-Inducible Factor 1α (HIF-1α) Expression
Xiaoxu Fang 1B* , Dandan Zhang 2CD* , Wei Zhao 3CD , Longfei Gao 4DE , Lanping Wang 5ABCDEF*DOI: 10.12659/MSM.924670
Med Sci Monit 2020; 26:e924670
Figure 1 Expression of DAAM1 and DAAM2 in HCCs and tumor-adjacent liver tissues. (A) mRNA levels of DAAM1 and DAAM2 in 19 pairs of HCCs and tumor-adjacent liver tissues were detected with qRT-PCR. (B) Overall view of the tissue microarray stained with DAAM2 antibody. (C) Expression and location of DAAM1 and DAAM2 in 117 pairs of HCCs and tumor-adjacent liver tissues were detected with IHC, and two cases of DAAM1/2 expression were displayed. Scale bar: 50 μm. (D) IHC scores of DAAM2 in 117 HCCs were substantially higher than those in adjacent tissues.