04 August 2020 : Database Analysis
TPX2 Promotes Metastasis and Serves as a Marker of Poor Prognosis in Non-Small Cell Lung Cancer
Fang Zhou1ACE, Meng Wang1D, Mijiti Aibaidula2F, Zhiguo Zhang2D, Abudusaimaiti Aihemaiti2B, Rezhake Aili2B, Hao Chen2B, Shuangfeng D Dong2B, Wei Wei2B, Abulizi Maimaitiaili2ACG*DOI: 10.12659/MSM.925147
Med Sci Monit 2020; 26:e925147
Figure 1 TPX2 was selected as the key candidate gene in regulating the malignant progression of NSCLC. (A) Heatmap analysis of DEGs revealed a substantial difference between circulating and nonmetastatic NSCLC tumor cells. (B) Volcano plot for the DEGs between circulating and nonmetastatic NSCLC tumor cells, where the red and green plots indicating the upregulated and downregulated genes, respectively. (C) PPI network analysis of DEGs revealed NSCLC-related PPI hubs, and topological PPI network indicated TPX2 as a key node gene. DEGs – differentially expressed genes; CTCs – circulating tumor cells; Ctrl – nonmetastatic NSCLC tumor cells; PPI – protein–protein interaction.