04 August 2020>: Database Analysis
TPX2 Promotes Metastasis and Serves as a Marker of Poor Prognosis in Non-Small Cell Lung Cancer
Fang Zhou 1ACE , Meng Wang 1D , Mijiti Aibaidula 2F , Zhiguo Zhang 2D , Abudusaimaiti Aihemaiti 2B , Rezhake Aili 2B , Hao Chen 2B , Shuangfeng Dong 2B , Wei Wei 2B , Abulizi Maimaitiaili 2ACG*DOI: 10.12659/MSM.925147
Med Sci Monit 2020; 26:e925147
Figure 1 TPX2 was selected as the key candidate gene in regulating the malignant progression of NSCLC. (A) Heatmap analysis of DEGs revealed a substantial difference between circulating and nonmetastatic NSCLC tumor cells. (B) Volcano plot for the DEGs between circulating and nonmetastatic NSCLC tumor cells, where the red and green plots indicating the upregulated and downregulated genes, respectively. (C) PPI network analysis of DEGs revealed NSCLC-related PPI hubs, and topological PPI network indicated TPX2 as a key node gene. DEGs – differentially expressed genes; CTCs – circulating tumor cells; Ctrl – nonmetastatic NSCLC tumor cells; PPI – protein–protein interaction.