01 October 2020 : Database Analysis
COL3A1, COL6A3, and SERPINH1 Are Related to Glucocorticoid-Induced Osteoporosis Occurrence According to Integrated Bioinformatics Analysis
Liuxun Li1ABCDEF, Meiling Yang2BCDEF, Anmin Jin1ABCDEFG*DOI: 10.12659/MSM.925474
Med Sci Monit 2020; 26:e925474
Figure 7 Hub gene validation based on training set (GSE30159). The mRNA level of 10 hub genes was validated in GIOP samples compared with normal samples. All hub genes except POSTN revealed statistically significant differences in GIOP. (A) COL3A1, (B) POSTN, (C) COL6A3, (D) COL14A1, (E) SERPINH1, (F) ASPN, (G) OGN, (H) THY1, (I) NID2, (J) TNMD. * P<0.05, ** P<0.01, *** P<0.001, NS – not significant. GIOP – glucocorticoid-induced osteoporosis; NON-GIOP – control group; COL3A1 – collagen type III alpha 1 chain; POSTN – periostin; COL6A3 – collagen type VI alpha 3 chain; COL14A1 – collagen type XIV alpha 1 chain; SERPINH1 – serpin family H member 1; ASPN – asporin; OGN – osteoglycin; THY1 – Thy-1 cell surface antigen; NID2 – nidogen 2; TNMD – tenomodulin.