01 October 2020 : Database Analysis
COL3A1, COL6A3, and SERPINH1 Are Related to Glucocorticoid-Induced Osteoporosis Occurrence According to Integrated Bioinformatics Analysis
Liuxun Li1ABCDEF, Meiling Yang2BCDEF, Anmin Jin1ABCDEFG*DOI: 10.12659/MSM.925474
Med Sci Monit 2020; 26:e925474
Figure 8 Hub gene validation based on test set (GSE129228). The mRNA level of 10 hub genes was validated in GIOP model samples compared with normal samples. SERPINH1 and POSTN were significantly upregulated in GIOP model groups in comparison to non-GIOP groups. (A) SERPINH1, (B) COL3A1, (C) POSTN, (D) COL6A3, (E) ASPN, (F) OGN, (G) THY1, (H) NID2. * P<0.05, ** P<0.01; NS – not significant; CG – control group; DEX – dexamethasone; GIOP – glucocorticoid-induced osteoporosis; SERPINH1 – serpin family H member 1; POSTN – periostin; COL3A1 – collagen type III alpha 1 chain; COL6A3 – collagen type VI alpha 3 chain; ASPN – asporin; OGN – osteoglycin; THY1 – Thy-1 cell surface antigen; NID2 – nidogen 2.