02 September 2020 : Clinical Research
miR-22-3p Suppresses Endothelial Progenitor Cell Proliferation and Migration via Inhibiting Onecut 1 (OC1)/Vascular Endothelial Growth Factor A (VEGFA) Signaling Pathway and Its Clinical Significance in Venous Thrombosis
Huoqi Liang1ABDE, Yibiao Chen1BCDF, Hefei Li1CDF, Xiaoqiang Yu1CEF, Chunqiu Xia1CF, Zhibing Ming1AEG*, Chongjun Zhong1AFGDOI: 10.12659/MSM.925482
Med Sci Monit 2020; 26:e925482
Figure 2 Effect of miR-22-3p on the biological function of endothelial progenitor cells (EPCs). (A) Proliferation assay showing knockdown of miR-22-3p promoted cell proliferation. (B) Statistical analysis of transwell assay revealed that inhibition of miR-22-3p increased migration of EPCs. (C) Representative microscopic images of cells that invaded through the transwell. (D) EPCs transfected with miR-22-3p inhibitor showed more migrated distance. (E) Statistical results from wound-healing assay. * P<0.05; ** P<0.01.