23 June 2020 : Laboratory Research
A PD-L1 Aptamer Selected by Loss-Gain Cell-SELEX Conjugated with Paclitaxel for Treating Triple-Negative Breast Cancer
Xiaoqiu Wu123BEF, Fangfei Li123AG, Yongshu Li1BF, Yuanyuan Yu13DF, Chao Liang13C, Baoting Zhang4DE, Chuanzong Zhao56B, Aiping Lu12378AG, Ge Zhang123AG*DOI: 10.12659/MSM.925583
Med Sci Monit 2020; 26:e925583
Figure 5 PD-L1 is the target protein for XQ-P3. (A) Internalized assay of aptamer XQ-P3 in MDA-MB-231 PD-L1 OE cells after incubation at 37°C for 2 hours. (B) Different concentrations of XQ-P3 based PD-L1 pull down assay. His tagged PD-L1 protein was immobilized on the Ni-NTA magnetic agarose beads and then incubated with the indicated concentration of DNA.