23 June 2020 : Laboratory Research
A PD-L1 Aptamer Selected by Loss-Gain Cell-SELEX Conjugated with Paclitaxel for Treating Triple-Negative Breast Cancer
Xiaoqiu Wu123BEF, Fangfei Li123AG, Yongshu Li1BF, Yuanyuan Yu13DF, Chao Liang13C, Baoting Zhang4DE, Chuanzong Zhao56B, Aiping Lu12378AG, Ge Zhang123AG*DOI: 10.12659/MSM.925583
Med Sci Monit 2020; 26:e925583
Figure 7 The effect of XQ-P3 modification on the uptake and cytotoxicity of conjugated PTX. (A) XQ-P3 modification dramatically increased the uptake of PTX in MDA-MB-231 PD-L1 OE cells and HCC1937 cells but not in MDA-MB-231 PD-L1 KO cells. (B) The cytotoxicity of conjugated PTX with XQ-P3 modification were also increased in MDA-MB-231 PD-L1 OE cells and HCC1937 cells but not in MDA-MB-231 PD-L1 KO cells. The data were presented as the means±standard deviation. n =3. RS, a random sequence served as a negative control of XQ-P3 aptamer. Error bars indicate mean±standard deviation.