05 October 2020 : Animal Research
The Protein Kinase R Inhibitor C16 Alleviates Sepsis-Induced Acute Kidney Injury Through Modulation of the NF-κB and NLR Family Pyrin Domain-Containing 3 (NLPR3) Pyroptosis Signal Pathways
Jialu Zhou1B, Fan Zhang2B, Hongru Lin1B, Minxue Quan1B, Yaqin Yang1B, Yanni Lv3C, Zongnan He4CE, Yisong Qian1ACE*DOI: 10.12659/MSM.926254
Med Sci Monit 2020; 26:e926254

Figure 1 C16 ameliorates sepsis-induced acute kidney injury in mice. (A) Representative hematoxylin and eosin-stained paraffin sections of kidney. Damage is indicated by arrows. (a: Tubular dilation and distortion. b: Necrosis. c: Interstitial hemorrhage. d: Infiltration of inflammatory cells.) Scale bar, 50 μm. (B) Histopathological score for the kidney. (C) Blood urea nitrogen in serum. (D) Creatinine levels in serum. Data are shown as mean ± standard deviation (n=8). ** P<0.01.