05 October 2020 : Animal Research
The Protein Kinase R Inhibitor C16 Alleviates Sepsis-Induced Acute Kidney Injury Through Modulation of the NF-κB and NLR Family Pyrin Domain-Containing 3 (NLPR3) Pyroptosis Signal Pathways
Jialu Zhou1B, Fan Zhang2B, Hongru Lin1B, Minxue Quan1B, Yaqin Yang1B, Yanni Lv3C, Zongnan He4CE, Yisong Qian1ACE*DOI: 10.12659/MSM.926254
Med Sci Monit 2020; 26:e926254

Figure 2 C16 inhibits renal inflammatory responses after lipopolysaccharide (LPS) injection. Real-time polymerase chain reaction was used to measure renal levels of proinflammatory cytokines and chemokines after LPS injection. (A) Tumor necrosis factor α. (B) Interleukin (IL)-1β. (C) IL-6. (D) Monocyte chemoattractant protein-1. (E) inducible nitric oxide synthase. (F) Cyclooxygenase-2. Data are presented as mean±standard deviation (n=6). * P<0.05, ** P<0.01.