05 October 2020 : Animal Research
The Protein Kinase R Inhibitor C16 Alleviates Sepsis-Induced Acute Kidney Injury Through Modulation of the NF-κB and NLR Family Pyrin Domain-Containing 3 (NLPR3) Pyroptosis Signal Pathways
Jialu Zhou1B, Fan Zhang2B, Hongru Lin1B, Minxue Quan1B, Yaqin Yang1B, Yanni Lv3C, Zongnan He4CE, Yisong Qian1ACE*DOI: 10.12659/MSM.926254
Med Sci Monit 2020; 26:e926254

Figure 3 C16 prevents NF-κB activation in lipopolysaccharide-induced acute kidney injury. (A) Immunoblots of phospho-IKKα/β (pIKKα/β), total IKKα (IKKα), total IKKβ (IKKβ), phospho-NF-κB p65 (pp65), total NF-κB p65 (p65), phospho-IκBα (pIκBα), total IκBα (IκBα), and glyceraldehyde-3-phosphate dehydrogenase. The levels of (B) pIKKα/β, (C) pp65, (D) pIκBα, and (E) IκBα were quantitatively analyzed and are shown as mean± standard deviation (n=6). * P<0.05, ** P<0.01.