05 October 2020>: Animal Study
The Protein Kinase R Inhibitor C16 Alleviates Sepsis-Induced Acute Kidney Injury Through Modulation of the NF-κB and NLR Family Pyrin Domain-Containing 3 (NLPR3) Pyroptosis Signal Pathways
Jialu Zhou 1B* , Fan Zhang 2B* , Hongru Lin 1B , Minxue Quan 1B , Yaqin Yang 1B , Yanni Lv 3C , Zongnan He 4CE* , Yisong Qian 1ACE*DOI: 10.12659/MSM.926254
Med Sci Monit 2020; 26:e926254
Figure 4 C16 suppresses the renal protein kinase R (PKR)/eIF2α signaling pathway. (A) Immunoblots of phospho-PKR (pPKR), total PKR (PKR), phospho-eIF2α (peIF2α), total eIF2α (eIF2α), and glyceraldehyde-3-phosphate dehydrogenase. The levels of (B) pPKR and (C) peIF2α were quantitatively analyzed and are shown as mean±standard deviation (n=8). **P<0.01.