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05 October 2020 : Animal Research  

The Protein Kinase R Inhibitor C16 Alleviates Sepsis-Induced Acute Kidney Injury Through Modulation of the NF-κB and NLR Family Pyrin Domain-Containing 3 (NLPR3) Pyroptosis Signal Pathways

Jialu Zhou1B, Fan Zhang2B, Hongru Lin1B, Minxue Quan1B, Yaqin Yang1B, Yanni Lv3C, Zongnan He4CE, Yisong Qian1ACE*

DOI: 10.12659/MSM.926254

Med Sci Monit 2020; 26:e926254

Figure 4 C16 suppresses the renal protein kinase R (PKR)/eIF2α signaling pathway. (A) Immunoblots of phospho-PKR (pPKR), total PKR (PKR), phospho-eIF2α (peIF2α), total eIF2α (eIF2α), and glyceraldehyde-3-phosphate dehydrogenase. The levels of (B) pPKR and (C) peIF2α were quantitatively analyzed and are shown as mean±standard deviation (n=8). **P<0.01.

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750