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20 October 2020 : Laboratory Research  

Verteporfin Promotes the Apoptosis and Inhibits the Proliferation, Migration, and Invasion of Cervical Cancer Cells by Downregulating SULT2B1 Expression

Lijun Yin1BCDEF, Guilin Chen2AF*

DOI: 10.12659/MSM.926780

Med Sci Monit 2020; 26:e926780

Figure 5 SULT2B1 overexpression weakened the inhibiting effect of verteporfin (VP) on the proliferation of cervical cancer cells. (A) The mRNA expression of SULT2B1 in HeLa cells after transfection was detected by RT-qPCR analysis. *** P<0.001 vs. Control group. ### P<0.001 vs. OE-NC group. (B) The protein expression of SULT2B1 in HeLa cells after transfection was detected by western blot analysis. * P<0.05 vs. Control group. # P<0.05 vs. OE-NC group. (C) The cell viability of HeLa cells after transfection and VP treatment was analyzed by CCK-8 assay. * P<0.05 and *** P<0.001 vs. Control group. ### P<0.001 vs. VP group. @@@ P<0.001 vs. VP+OE-NC group. (D) The clone formation ability of HeLa cells after transfection and VP treatment was determined by clone formation assay.

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750