Epigallocatechin Gallate (EGCG) Improves Anti-Angiogenic State, Cell Viability, and Hypoxia-Induced Endothelial Dysfunction by Downregulating High Mobility Group Box 1 (HMGB1) in Preeclampsia

Min Zhong; Julan Peng; Lanhua Xiang; Xinhuang Yang; Xianghua Wang; Yanbin Zhu

doi:10.12659/MSM.926924

15 October 2020 : Laboratory Research

Epigallocatechin Gallate (EGCG) Improves Anti-Angiogenic State, Cell Viability, and Hypoxia-Induced Endothelial Dysfunction by Downregulating High Mobility Group Box 1 (HMGB1) in Preeclampsia

Min Zhong^1ABCDEFG, Julan Peng^1ABCDEFG, Lanhua Xiang^1ABCDEFG, Xinhuang Yang^1ABCDEFG, Xianghua Wang^1ABCDEFG, Yanbin Zhu^2ABCDEFG*

DOI: 10.12659/MSM.926924

Med Sci Monit 2020; 26:e926924

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Figure 2 EGCG relieved anti-angiogenic state in hypoxic trophoblast cells by downregulating HMGB1. (A) VEGF production detected by ELISA assay; (B) sFlt1 production detected by ELISA assay. * p<0.05, ** p<0.01.

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Epigallocatechin Gallate (EGCG) Improves Anti-Angiogenic State, Cell Viability, and Hypoxia-Induced Endothelial Dysfunction by Downregulating High Mobility Group Box 1 (HMGB1) in Preeclampsia

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