01 February 2021: Clinical Research
Functional Doxorubicin-Loaded Omega-3 Unsaturated Fatty Acids Nanoparticles in Reversing Hepatocellular Carcinoma Multidrug Resistance
Chunlei Wang 12ABEFG , Xiaoyan Wei 12BDF , Guoliang Shao 12ACFG*DOI: 10.12659/MSM.927727
Med Sci Monit 2021; 27:e927727
Figure 5 Protein expressions of drug efflux transporters, MRP, LRP, BCRP, Bcl-2, and PKC-α in HepG2 or HepG2/DOX cells. The protein expression was detected using western blotting, and β-actin was used as the internal control. Compared with the HepG2/DOX group, @ P<0.05, @@ P<0.01; compared with the HepG2+DOX-nano group, # P<0.05, ## P<0.01; compared with the HepG2/DOX+DOX group, * P<0.05, ** P<0.01. BCRP – breast cancer resistance protein; Bcl-2 – B-cell lymphoma 2; DOX – doxorubicin; DOX-nano – doxorubicin-loaded docosahexaenoic acid nanoparticles; LRP – lung resistance protein; MRP – multidrug resistance protein; PKC-α – protein kinase C alpha.