09 March 2021 : Animal Research
Effects of Pretreatment with Bifidobacterium bifidum Using 16S Ribosomal RNA Gene Sequencing in a Mouse Model of Acute Colitis Induced by Dextran Sulfate Sodium
Yi-jie Weng1BCDEF, Dan-xian Jiang2BCDEF, Jian Liang1BCDF, Shi-cai Ye1BCD, Wen-kai Tan1BCF, Cai-yuan Yu1BCF, Yu Zhou1ACDEG*DOI: 10.12659/MSM.928478
Med Sci Monit 2021; 27:e928478
Figure 5 Changes in the microbial communities in the pretreated group. (A) The top 10 most frequently observed bacterial phyla in the communities. (B) The Shannon diversity index was higher in mice that received Bifidobacterium bifidum supplements for 3 weeks than in mice assessed on the day of sacrifice. The principal coordinate analysis (C) and unweighted pair group method with arithmetic mean tree (D) showed that the microbiota was initially clustered by different time points and treatments. Different features in the control and B. bifidum-pretreated groups on the day of sacrifice were identified using linear discriminate analysis effect size, with a local-density approximation value of 4.0 (E, F).