Figure 1 Induction of inflammatory factor secretion and oxidative stress by thrombin in H/R-injured cardiomyocytes. (A) MDA content, ROS level, and SOD activity were detected to evaluate oxidative stress in the H/R model treated with thrombin, the H/R model treated with dabigatran, and the H/R model treated with a combination of thrombin and dabigatran, as well as the controls. (B) ELISA was used to determine the level of IL-1b, IL-6, TNF-a, ICAM-1, and MMP-9. (C) MTT was conducted to test cell viability. *** P<0.001 vs control group, n=3.