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01 May 2021: Lab/In Vitro Research

Thrombin Aggravates Hypoxia/Reoxygenation Injury of Cardiomyocytes by Activating an Autophagy Pathway-Mediated by SIRT1

Xiaoning Wang 1A , Yunhe Xu 2BC , Lingbo Li 3F , Weiwei Lu 1EF*

DOI: 10.12659/MSM.928480

Med Sci Monit 2021; 27:e928480

Figure 2 Induction of autophagy by thrombin in H/R-injured cardiomyocytes. (A) Western blotting was applied to determine the level of thrombin, PAR-1, SIRT1, Beclin1, and the conversion of LC3I to LC3II. (B) qRT-PCR was conducted to detect the expression of thrombin, PAR-1, and SIRT1. *** P<0.001 vs control group, n=3.

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750