01 May 2021 : Laboratory Research
Thrombin Aggravates Hypoxia/Reoxygenation Injury of Cardiomyocytes by Activating an Autophagy Pathway-Mediated by SIRT1
Xiaoning Wang1A, Yunhe Xu2BC, Lingbo Li3F, Weiwei Lu1EF*DOI: 10.12659/MSM.928480
Med Sci Monit 2021; 27:e928480
Figure 2 Induction of autophagy by thrombin in H/R-injured cardiomyocytes. (A) Western blotting was applied to determine the level of thrombin, PAR-1, SIRT1, Beclin1, and the conversion of LC3I to LC3II. (B) qRT-PCR was conducted to detect the expression of thrombin, PAR-1, and SIRT1. *** P<0.001 vs control group, n=3.