06 November 2020: Review Articles
Mitochondrial Fusion and Fission in Neuronal Death Induced by Cerebral Ischemia-Reperfusion and Its Clinical Application: A Mini-Review
Yike Chen 1BC* , Songxue Guo 2D* , Yajuan Tang 1E , Chaohui Mou 3F , Xinben Hu 1C , Fangjie Shao 1BD , Wei Yan 1A , Qun Wu 1AG*DOI: 10.12659/MSM.928651
Med Sci Monit 2020; 26:e928651
Introduction to Cerebral Ischemia-Reperfusion
Mitochondrial Dynamics
Mitochondria and Ischemia-Reperfusion (I/R) Injury
Mitochondrial Fusion and Fission
Maintaining the Balance Between Mitochondrial Fusion and Fission
Dysfunctional Mitochondria in Neurons During the I/R Process
Unbalanced Mitochondrial Fusion/Fission Process Leads to Neuronal Apoptosis
Mitochondrial Autophagy Is Involved in Neuronal Death During I/R
Mitochondrial Dynamics and Other Forms of Neuronal Death Induced by I/R
Molecular Mechanisms Underlying Dysfunctional Mitochondrial Dynamics During the I/R Process
Experimental Interventions Targeting Dysfunctional Mitochondrial Dynamics Induced by I/R
Cerebral Ischemia-Reperfusion Drugs Targeting Mitochondrial Dysfunction
Drugs Targeting Mitochondrial ATP Channel
Drugs Targeting Mitochondrial Ca2
Conclusions
References
Figure 1 Drp1 phosphorylation/dephosphorylation and mitochondrial fission in neurons upon I/R. I/R activates Cdk1/cyclin B to induce the phosphorylation of Drp1 at serine 616, leading to mitochondrial fission via and promoting the activation/recruitment of Drp1. I/R promotes PINK1 expression to suppress the Drp1 phosphorylation at serine 616, suppressing the activation/recruitment of Drp1 and mitochondrial fission. I/R activates calcineurin, leading to Drp1 Ser637/656 dephosphorylation, increasing Drp1 activity and promoting mitochondrial fission.