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06 November 2020: Review Articles

Mitochondrial Fusion and Fission in Neuronal Death Induced by Cerebral Ischemia-Reperfusion and Its Clinical Application: A Mini-Review

Yike Chen 1BC* , Songxue Guo 2D* , Yajuan Tang 1E , Chaohui Mou 3F , Xinben Hu 1C , Fangjie Shao 1BD , Wei Yan 1A , Qun Wu 1AG*

DOI: 10.12659/MSM.928651

Med Sci Monit 2020; 26:e928651

Figure 2 Drp1 SUMOylation/deSUMOylation and mitochondrial fission in neurons upon I/R. During ischemia, Drp1 SUMOylation by SUMO-2/3 contributes to reduced mitochondrial fission; however, after reperfusion, SENP3 levels are restored, leading to the deSUMOylation of Drp1-SUMO2/3 and increased mitochondrial fission.

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750