06 November 2020>: Review Articles
Mitochondrial Fusion and Fission in Neuronal Death Induced by Cerebral Ischemia-Reperfusion and Its Clinical Application: A Mini-Review
Yike Chen 1BC* , Songxue Guo 2D* , Yajuan Tang 1E , Chaohui Mou 3F , Xinben Hu 1C , Fangjie Shao 1BD , Wei Yan 1A , Qun Wu 1AG*DOI: 10.12659/MSM.928651
Med Sci Monit 2020; 26:e928651
Figure 2 Drp1 SUMOylation/deSUMOylation and mitochondrial fission in neurons upon I/R. During ischemia, Drp1 SUMOylation by SUMO-2/3 contributes to reduced mitochondrial fission; however, after reperfusion, SENP3 levels are restored, leading to the deSUMOylation of Drp1-SUMO2/3 and increased mitochondrial fission.