27 May 2021: Animal Study
Acupuncture Can Play an Antidepressant Role by Regulating the Intestinal Microbes and Neurotransmitters in a Rat Model of Depression
Peng Li 1E* , Wenya Huang 1E* , Yi-ning Yan 2B , Wenjing Cheng 1C , Siyu Liu 3C , Yang Huang 1C , Wenjie Chen 1C , Yi-ping Chen 4D , Yuxun Gao 1D , Weicheng Lu 1B , Yijing Xu 1B , Xianjun Meng 1AG*DOI: 10.12659/MSM.929027
Med Sci Monit 2021; 27:e929027
Figure 5 Statistical graph of β-CaMKII/NMDAR/BDNF protein expression in the rat hippocampus. (A) Expression of BDNF proteins in the hippocampus by western blotting. (B) Expression of β-CaMKII proteins in the hippocampus by western blotting. (C) Expression of NMDAR proteins in the hippocampus by western blotting. (D) Analysis of BDNF proteins. (E) Analysis of β-CaMKII proteins. (F) Analysis of NMDAR proteins. Compared with the control (Con) group, * P<0.05, ** P<0.01, *** P<0.001; compared with the chronic unpredictable mild stress (CUMS) group, # P<0.05, ## P<0.01, ### P<0.001. Data represent mean±standard error of the mean. AP – acupuncture; BDNF – brain-derived neurotrophic factor; β-CaMKII – β isoform of calcium/calmodulin-dependent protein kinase II; Fx – fluoxetine; NMDAR – N-methyl-d-aspartate receptor.