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27 May 2021 : Animal Research  

Acupuncture Can Play an Antidepressant Role by Regulating the Intestinal Microbes and Neurotransmitters in a Rat Model of Depression

Peng Li1E, Wenya Huang1E, Yi-ning Yan2B, Wenjing Cheng1C, Siyu Liu3C, Yang Huang1C, Wenjie Chen1C, Yi-ping Chen4D, Yuxun Gao1D, Weicheng Lu1B, Yijing Xu1B, Xianjun Meng1AG*

DOI: 10.12659/MSM.929027

Med Sci Monit 2021; 27:e929027

Figure 5 Statistical graph of β-CaMKII/NMDAR/BDNF protein expression in the rat hippocampus. (A) Expression of BDNF proteins in the hippocampus by western blotting. (B) Expression of β-CaMKII proteins in the hippocampus by western blotting. (C) Expression of NMDAR proteins in the hippocampus by western blotting. (D) Analysis of BDNF proteins. (E) Analysis of β-CaMKII proteins. (F) Analysis of NMDAR proteins. Compared with the control (Con) group, * P<0.05, ** P<0.01, *** P<0.001; compared with the chronic unpredictable mild stress (CUMS) group, # P<0.05, ## P<0.01, ### P<0.001. Data represent mean±standard error of the mean. AP – acupuncture; BDNF – brain-derived neurotrophic factor; β-CaMKII – β isoform of calcium/calmodulin-dependent protein kinase II; Fx – fluoxetine; NMDAR – N-methyl-d-aspartate receptor.

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750