27 May 2021: Animal Study
Acupuncture Can Play an Antidepressant Role by Regulating the Intestinal Microbes and Neurotransmitters in a Rat Model of Depression
Peng Li 1E* , Wenya Huang 1E* , Yi-ning Yan 2B , Wenjing Cheng 1C , Siyu Liu 3C , Yang Huang 1C , Wenjie Chen 1C , Yi-ping Chen 4D , Yuxun Gao 1D , Weicheng Lu 1B , Yijing Xu 1B , Xianjun Meng 1AG*DOI: 10.12659/MSM.929027
Med Sci Monit 2021; 27:e929027
Figure 7 Effect of acupuncture on the diversity and richness of intestinal flora in chronic unpredictable mild stress (CUMS) rats. (A) The Shannon index value indicates the diversity of samples. (B) Principal coordinates analysis (PCoA) for the distance between samples (β diversity) calculated using unweighted UniFrac distance. (C) A Venn diagram of the operational taxonomic units (OTUs) analyzes samples of different groups. (D) Relative abundance analysis at the phylum level. (E) Relative abundance of Firmicutes at the phylum level. (F) Relative abundance of Bacteroidetes at the phylum level. (G) Relative abundance of Bacteroidetes/Firmicutes at the phylum level. Compared with the control (Con) group, * P<0.05, ** P<0.01, *** P<0.001; compared with the CUMS group, # P<0.05, ## P<0.01, ### P<0.001. Data represent mean±standard error of the mean. AP – acupuncture; Fx – fluoxetine group.