Zi Qi Decoction Alleviates Liver Fibrosis by Inhibiting the Toll-Like Receptor 4 (TLR4)-Related Nuclear Factor kappa b (NF-κB) and Mitogen-Activated Protein Kinase (MAPK) Signaling Pathways

Jingwen Zhou; Xiaolong Zhang; Lingfeng Wan; Jun Yu; Tianci Li; Ziyu Lu; Nanyuan Fang; Lixia Sun; Fang Ye

doi:10.12659/MSM.929438

14 April 2021 : Animal Research

Zi Qi Decoction Alleviates Liver Fibrosis by Inhibiting the Toll-Like Receptor 4 (TLR4)-Related Nuclear Factor kappa b (NF-κB) and Mitogen-Activated Protein Kinase (MAPK) Signaling Pathways

Jingwen Zhou^1ABCE, Xiaolong Zhang^1A, Lingfeng Wan^1AD, Jun Yu^2BCD, Tianci Li^2BCD, Ziyu Lu^3BCD, Nanyuan Fang^1E, Lixia Sun^1AG, Fang Ye^2AG*

DOI: 10.12659/MSM.929438

Med Sci Monit 2021; 27:e929438

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Figure 1 Zi Qi decoction plays a role in preventing activation of hepatic stellate cells. (A) The effects of Zi Qi decoction on cell viability at different concentrations. (B) The effects of Zi Qi decoction on the relative messenger RNA level of cellular Types I and III collagen and α-SMA at different concentrations. (C) The effects of Zi Qi decoction on the protein level of cellular Types I and III collagen and α-SMA at different concentrations. * P<0.05, ** P<0.01, *** P<0.001, compared with the LPS group. Data were presented as means±standard deviations.

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Zi Qi Decoction Alleviates Liver Fibrosis by Inhibiting the Toll-Like Receptor 4 (TLR4)-Related Nuclear Factor kappa b (NF-κB) and Mitogen-Activated Protein Kinase (MAPK) Signaling Pathways

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