Zi Qi Decoction Alleviates Liver Fibrosis by Inhibiting the Toll-Like Receptor 4 (TLR4)-Related Nuclear Factor kappa b (NF-κB) and Mitogen-Activated Protein Kinase (MAPK) Signaling Pathways

Jingwen Zhou; Xiaolong Zhang; Lingfeng Wan; Jun Yu; Tianci Li; Ziyu Lu; Nanyuan Fang; Lixia Sun; Fang Ye

doi:10.12659/MSM.929438

14 April 2021 : Animal Research

Zi Qi Decoction Alleviates Liver Fibrosis by Inhibiting the Toll-Like Receptor 4 (TLR4)-Related Nuclear Factor kappa b (NF-κB) and Mitogen-Activated Protein Kinase (MAPK) Signaling Pathways

Jingwen Zhou^1ABCE, Xiaolong Zhang^1A, Lingfeng Wan^1AD, Jun Yu^2BCD, Tianci Li^2BCD, Ziyu Lu^3BCD, Nanyuan Fang^1E, Lixia Sun^1AG, Fang Ye^2AG*

DOI: 10.12659/MSM.929438

Med Sci Monit 2021; 27:e929438

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Figure 4 Effects of Zi Qi decoction on collagen deposition in liver tissue. (A) The effects of Zi Qi decoction on the relative messenger RNA level of Types I and III collagen and α-SMA in liver tissue of hepatic fibrosis rats. (B) The effects of Zi Qi decoction on the protein level of Types I and III collagen and α-SMA in liver tissue in each group. (C) Immunohistochemical staining assay of α-SMA and Type I collagen. Magnification ×200. ### P<0.001, compared with the control group. * P<0.05, ** P<0.01, *** P<0.001, compared with the vehicle group. Data were presented as means±standard deviations.

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Zi Qi Decoction Alleviates Liver Fibrosis by Inhibiting the Toll-Like Receptor 4 (TLR4)-Related Nuclear Factor kappa b (NF-κB) and Mitogen-Activated Protein Kinase (MAPK) Signaling Pathways

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