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14 April 2021 : Animal Research  

Zi Qi Decoction Alleviates Liver Fibrosis by Inhibiting the Toll-Like Receptor 4 (TLR4)-Related Nuclear Factor kappa b (NF-κB) and Mitogen-Activated Protein Kinase (MAPK) Signaling Pathways

Jingwen Zhou1ABCE, Xiaolong Zhang1A, Lingfeng Wan1AD, Jun Yu2BCD, Tianci Li2BCD, Ziyu Lu3BCD, Nanyuan Fang1E, Lixia Sun1AG, Fang Ye2AG*

DOI: 10.12659/MSM.929438

Med Sci Monit 2021; 27:e929438

Figure 5 Toll-like receptor 4 (TLR4)-related nuclear factor kappa b (NF-κB) and mitogen-activated protein kinase (MAPK) signaling pathways were inhibited by Zi Qi decoction in vivo. (A) Messenger RNA expression of TLR4, MyD88, and TRAF6 in liver tissue in each group. (B) Protein expression of TLR4, MyD88, TRAF6, and phospho-NF-κB p65 in liver tissue in each group. (C) Expression of MAPK pathway-related proteins and their relative phosphorylation levels in liver tissue in each group. # P<0.05, compared with the control group. * P<0.05, *** P<0.001, compared with the vehicle group. Data were presented as means±standard deviations.

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750