Left Ventricular Impaired Relaxation and Interstitial Myocarditis Identified in Sepsis-Associated Cardiac Dysfunction: Use of a Rodent Model

David J. Sturgess; Shannon Morrison; Brian Haluska; Glenda C. Gobe; Mark A. Jones; Sonia Volante; Bala Venkatesh

doi:10.12659/MSM.929512

18 April 2021 : Animal Research

Left Ventricular Impaired Relaxation and Interstitial Myocarditis Identified in Sepsis-Associated Cardiac Dysfunction: Use of a Rodent Model

David J. Sturgess^1ABCDEFG*, Shannon Morrison^1BCDE, Brian Haluska^2BCD, Glenda C. Gobe^23BCDEG, Mark A. Jones^4ACDE, Sonia Volante^1BE, Bala Venkatesh^2ACDEG

DOI: 10.12659/MSM.929512

Med Sci Monit 2021; 27:e929512

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Figure 1 Heart histopathology and immunohistochemistry (IHC). Panels on left are examples of control hearts and on right are LPS treatments. A and B are hematoxylin and eosin stains showing clear hydropic change in the cells of the LPS treatment. C and D contrast ED1 IHC (monocyte/macrophage) with examples of labeled cells arrowed in D. E and F contrast activated caspase-3 IHC (apoptotic cells) with examples arrowed in F and negligible labeling in E.

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Left Ventricular Impaired Relaxation and Interstitial Myocarditis Identified in Sepsis-Associated Cardiac Dysfunction: Use of a Rodent Model

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