06 April 2021>: Review ArticlesQingtai Cao 1B*2 , HanYu Lei 3E* , MengLing Yang 23B* , Le Wei 23A , YinMiao Dong 23E , JiaHao Xu 23F , Mi Nasser 4C , MengQi Liu 23F , Ping Zhu 4G* , LinYong Xu 5G* , MingYi Zhao 2AG
Med Sci Monit 2021; 27:e930032
Figure 1 SARS-CoV-2 downregulates ACE2 to cause cardiovascular injuries. SARS-CoV-2 downregulates ACE2 by suppressing transcription of the ACE2 gene, cutting the extracellular segment of ACE2, and increasing internalization with ACE2, leading to increased Ang II expression and TACE activation, thus elevating the expression level of TNF-α and the risk of cardiovascular adverse events. The downregulation of ACE2 occurring in the heart, lung, hypothalamus, and kidney can all increase the load on the cardiovascular system.