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06 April 2021: Review Articles

Impact of Cardiovascular Diseases on COVID-19: A Systematic Review

Qingtai Cao 1B*2 , HanYu Lei 3E* , MengLing Yang 23B* , Le Wei 23A , YinMiao Dong 23E , JiaHao Xu 23F , Mi Nasser 4C , MengQi Liu 23F , Ping Zhu 4G* , LinYong Xu 5G* , MingYi Zhao 2AG

DOI: 10.12659/MSM.930032

Med Sci Monit 2021; 27:e930032

Figure 2 Possible mechanisms for cardiovascular injuries after SARS-CoV-2 infection. a) Stress: Downregulation of ACE2 could lead to excessive Nox2 activation, inducing ROS accumulation. High levels of TNF-α and IL-6 can increase mitochondrial stress, leading to higher levels of oxidative stress. ER stress can destabilize atherosclerotic plaque through increasing NF-κB-induced GM-CSF. b) Hypoxia: SARS-CoV-2-related hypoxemia can affect the miR-146b-TRAF6-IL-6/CCL2 (MCP-1) axis and induce expression of HIMF, promoting the production of proinflammatory cytokines. c) Accumulation of proinflammatory cytokines contributes to cardiovascular complications. d) Drug-related injuries: Drugs administered in treating SARS-CoV-2 can cause cardiovascular complications. Chloroquine, lopinavir/ritonavir, and azithromycin can affect the normal rhythm of the heart. Lopinavir/ritonavir can also increase LDL and suppress HDL, destabilizing atherosclerotic plaque. Pegylated interferon-α can lead to the upregulation of TNF-α.

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750