08 December 2021 : Laboratory Research
Chemokine (C-C Motif) Ligand 2/Chemokine Receptor 2 (CCR2) Axis Blockade to Delay Chondrocyte Hypertrophy as a Therapeutic Strategy for Osteoarthritis
Zidong Wang1ACE, Bei Wang2CF, Jian Zhang1DF, Zhensong Wu3BD, Liankui Yu1BF, Zhongye Sun1ADG*DOI: 10.12659/MSM.930053
Med Sci Monit 2021; 27:e930053
Figure 5 Blocking chemokine (C-C motif) ligand 2/CCR2 delays interleukin-17A-induced chondrocyte hypertrophy. (A) mRNA expression of Type 2 collagen, RUNX2, and IHH was assessed with real-time polymerase chain reaction. (B) Cell proliferation was measured with an MTT assay. (C) Cell apoptosis was measured with flow cytometry. Data are shown as means±standard deviations versus the control group. * P<0.05, ** P<0.01, *** P<0.001.