20 August 2021>: Clinical Research
Association of Plasma Pro-Brain-Derived Neurotrophic Factor (proBDNF)/Mature Brain-Derived Neurotrophic Factor (mBDNF) Levels with Gene Val66Met Polymorphism in Alcohol Dependence
Min Mo 1BCDEG* , Xi-yue Fu 2BCDF* , Xu-lan Zhang 1BD , Shao-chuan Zhang 1BD , Hai-qing Zhang 1CD , Li Wu 1AF , Jia-lei Li 1AF , Li Zhou 1ACEFG*DOI: 10.12659/MSM.930421
Med Sci Monit 2021; 27:e930421
Figure 4 Correlations of plasma proBDNF and mBDNF levels with alcohol drinking history. Statistical analysis was performed with Spearman’s correlation test. (A) proBDNF (r=0.317, P=0.014) had a significant positive correlation with average daily ethanol consumption. (B) mBDNF (r=−0.427, P=0.001) had a significant negative correlation with total alcohol consumption. mBDNF – mature brain-derived neurotrophic factor; proBDNF – pro-brain-derived neurotrophic factor.