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03 April 2021: Animal Study

Expression of DUSP12 Reduces Lung Vascular Endothelial Cell Damage in a Murine Model of Lipopolysaccharide-Induced Acute Lung Injury via the Apoptosis Signal-Regulating Kinase 1 (ASK1)-Jun N-Terminal Kinase Activation (JNK) Pathway

Zhao Hui 1BF , Huang Jie 2CD , Guo-Hua Fan 2ABCDEFG*

DOI: 10.12659/MSM.930429

Med Sci Monit 2021; 27:e930429

Figure 1 DUSP12 suppressed LPS-induced lung injury in mice. (A, B) DUSP12 protein and mRNA levels in lung tissue after treatment with lipopolysaccharide (LPS) (* P<0.05 vs 0 h). (C) Protein level of DUSP12 in mouse lung tissue 42 h after Ad-DUSP12 injection (n=6). (D) Immunofluorescence staining of CD31 and DUSP12 after Ad-DUSP12 injection (n=5, magnification: 400). (E) Hematoxylin and eosin (H&E) staining (n=5, magnification: 200). (F) Lung wet weight/dry weight ratio (W/D ratio) (n=10). (G) Lung injury score (n=6). (H) Proinflammatory factor levels in alveolar lavage fluid as measured by ELISA (n=6). (* P<0.05 vs Ad-NC/NS; # P<0.05 vs Ad-NC/LPS).

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750