Expression of DUSP12 Reduces Lung Vascular Endothelial Cell Damage in a Murine Model of Lipopolysaccharide-Induced Acute Lung Injury via the Apoptosis Signal-Regulating Kinase 1 (ASK1)-Jun N-Terminal Kinase Activation (JNK) Pathway

Zhao Hui; Huang Jie; Guo-Hua Fan

doi:10.12659/MSM.930429

03 April 2021 : Animal Research

Expression of DUSP12 Reduces Lung Vascular Endothelial Cell Damage in a Murine Model of Lipopolysaccharide-Induced Acute Lung Injury via the Apoptosis Signal-Regulating Kinase 1 (ASK1)-Jun N-Terminal Kinase Activation (JNK) Pathway

Zhao Hui^1BF, Huang Jie^2CD, Guo-Hua Fan^2ABCDEFG*

DOI: 10.12659/MSM.930429

Med Sci Monit 2021; 27:e930429

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Figure 4 DUSP12 silencing worsened LPS-induced pulmonary endothelial cell injury. (A–E) MLECs were transfected with DUSP12 siRNA and treated with LPS. (A) Protein level of DUSP12 in MLECs transfected with siDUSP12. (B) mRNA levels of proinflammatory factors. (C) ELISA measurement of proinflammatory factors. (D) TUNEL staining (magnification: 200). (E) Caspase-3 activity (* P<0.05 vs ScRNA/PBS; # P<0.05 vs ScRNA/LPS). All in vitro studies were repeated 3 times independently.

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Expression of DUSP12 Reduces Lung Vascular Endothelial Cell Damage in a Murine Model of Lipopolysaccharide-Induced Acute Lung Injury via the Apoptosis Signal-Regulating Kinase 1 (ASK1)-Jun N-Terminal Kinase Activation (JNK) Pathway

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