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16 August 2021: Meta-Analysis

Prognostic Significance of Microvascular Invasion in Pancreatic Ductal Adenocarcinoma: A Systematic Review and Meta-Analysis

Huangbao Li 1ACEF , Weiwei Pan 2AEF , Liu Xu 1BE , Dong Yin 3CDE , Shuqun Cheng 34AEFG* , Fengqing Zhao 1AEF*

DOI: 10.12659/MSM.930545

Med Sci Monit 2021; 27:e930545

Figure 4 The mechanism of MVI in pancreatic cancer and the relationship between MVI and metastasis. (A) The mechanism of MVI in pancreatic cancer. (a) Tumor cells gain mobility and invasion capabilities through EMT. (b) Increased permeability of the microvascular endothelium facilitates tumor cells to invade into the microvasculature. (B) The relationship between MVI and metastasis. (1) Angiogenesis, leading to blood transfer and/or liver transfer through the portal vein. (2) Lymphangiogenesis, leading to metastasis to the draining lymph nodes. (3) Lymphangiogenesis, leading to metastasis to the lymphatic duct. EMT – epithelial-to-mesenchymal transition; MVI – microvascular invasion.

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750