16 August 2021>: Meta-Analysis
Prognostic Significance of Microvascular Invasion in Pancreatic Ductal Adenocarcinoma: A Systematic Review and Meta-AnalysisHuangbao Li 1ACEF , Weiwei Pan 2AEF , Liu Xu 1BE , Dong Yin 3CDE , Shuqun Cheng 34AEFG* , Fengqing Zhao 1AEF*
Med Sci Monit 2021; 27:e930545
Figure 4 The mechanism of MVI in pancreatic cancer and the relationship between MVI and metastasis. (A) The mechanism of MVI in pancreatic cancer. (a) Tumor cells gain mobility and invasion capabilities through EMT. (b) Increased permeability of the microvascular endothelium facilitates tumor cells to invade into the microvasculature. (B) The relationship between MVI and metastasis. (1) Angiogenesis, leading to blood transfer and/or liver transfer through the portal vein. (2) Lymphangiogenesis, leading to metastasis to the draining lymph nodes. (3) Lymphangiogenesis, leading to metastasis to the lymphatic duct. EMT – epithelial-to-mesenchymal transition; MVI – microvascular invasion.